24877.風疹病毒宿主細胞受體的研究

1、中國科學院研究生院博士學位論文風疹病毒宿主細胞受體的研究姓名：叢浩龍申請學位級別：博士專業(yè)：微生物學指導教師：田波2011IdentificationoftheGlycoproteinasaMyelinOligodendrocyteCellularReceptorforRubellaVirusAbstractRubellavirus(RV)isahighlytransmissiblepathogenicagentthatcausesth

2、ediseaseofrubellaRVconsistsofapositive—sense，single—strandedRNAgenomeenclosedinaquasisphericalcapsidandanenvelopeinwhichthetwotypeImembraneglycoproteins，E2andEl，areembeddedasaheterodimericspikecomplexTheclinicalsymptomso

3、fRVinfectionsacquiredpostnatallyareusuallymild，butmaternalinfectionduringthefirst8weeksafterthelastmenstrualperiodresultsinchronicnon—lyticinfectioninnearlyallfetuses，withalmostallinfectedfetusesdevelopingcongenitaldefec

4、tswhichentailsarangeofseriousincurableillnessesincludecardiac，cerebral，ophthalmicandauditorydefectsSpecificinteractionofvirionconstituentswithcellularsurfacecomponentsisessentialforinfectionoftargetcellsbyextracellularvi

5、rusparticlesForenvelopedviruses，suchasrubellavirus，thisprocessismainlymediatedbythespecificbindingofenvelopeproteinsofthevirusestocellreceptors，resultingintheattachmentofvirusparticlestothecellThoughmostevidenceindicates

6、thatafterattachmenttheRVisinternalizedtoanendosomevacuolebythefusionoftheviralenvelopetotheendosomalmembranefollowingconformationalchangesintheRVE1andE2glycoproteins，therouteandmechanismofRVentryintothehostcellisnotcompl