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簡(jiǎn)介：ORIGINALARTICLEALIMENTARYTRACTDOWNREGULATIONOFMIR141INGASTRICCANCERANDITSINVOLVEMENTINCELLGROWTHYINGDU?YANJUNXU?LINGDING?HAOMIYAO?HONGYU?TIANHUAZHOU?JIANMINSIRECEIVED18AUGUST2008/ACCEPTED28JANUARY2009/PUBLISHEDONLINE11APRIL2009?SPRINGER2009ABSTRACTPURPOSEHUMANMICRORNA141MIR141,AMEMBEROFTHEMIR200FAMILY,HASBEENREPORTEDTOBEASSOCIATEDWITHVARIOUSHUMANMALIGNANCIESHOWEVER,ITREMAINSUNKNOWNWHETHERMIR141ISINVOLVEDINTHEPATHOGENESISOFGASTRICCANCERTHEREFORE,WEEXAMINEDTHEEXPRESSIONOFMIR141INGASTRICCANCERTISSUESANDTHEEFFECTOFMIR141OVEREXPRESSIONONCANCERCELLPROLIFERATIONMETHODSTHEEXPRESSIONLEVELOFMIR141IN35PAIRMATCHEDGASTRICNEOPLASTICANDADJACENTNONNEOPLASTICTISSUES,ANDIN5GASTRICCANCERCELLLINESWEREEXAMINEDBYQUANTITATIVEREALTIMEPCRTHEGROWTHOFMGC803CELLSTRANSFECTEDWITHMIRNAPRECURSORWASEXAMINEDBYMTT34,5DIMETHYLTHIAZOL2YL2,5DIPHENYLTETRAZOLIUMBROMIDEASSAYRESULTSMIR141WASSIGNIFICANTLYDOWNREGULATEDIN8028/35OFPRIMARYGASTRICCANCERTISSUESCOMPAREDWITHPAIRMATCHEDADJACENTNONTUMORTISSUESP\001THEEXPRESSIONOFMIR141WASALSOFOUNDTOBESUBSTANTIALLYREDUCEDINSEVERALHUMANGASTRICCANCERCELLLINESSUCHASMGC803,HGC27,SGC7901ANDBGC823CELLSOVEREXPRESSIONOFMIR141WITHITSPRECURSORSSIGNIFICANTLYINHIBITEDTHEPROLIFERATIONOFGASTRICCANCERCELLSCONCLUSIONSTHESERESULTSSUGGESTTHATMIR141MAYBEINVOLVEDINTHEDEVELOPMENTOFGASTRICCANCERTHROUGHITSINHIBITORYEFFECTONCELLPROLIFERATIONKEYWORDSMIR141?GASTRICCANCER?MGC803CELL?CELLPROLIFERATIONINTRODUCTIONMICRORNASMIRNAS,ANEWCLASSOFENDOGENOUS,NONCODINGANDSINGLESTRANDEDRNAS,WERERECENTLYDISCOVEREDINBOTHANIMALSANDPLANTSTHEYTRIGGERTRANSLATIONALREPRESSIONAND/ORMRNADEGRADATIONMOSTLYTHROUGHCOMPLEMENTARYBINDINGTOTHE30UNTRANSLATEDREGIONSOFTARGETMRNASSTUDIESHAVESHOWNTHATMIRNASCANREGULATEAWIDEARRAYOFBIOLOGICALPROCESSESSUCHASCELLPROLIFERATION,DIFFERENTIATION,ANDAPOPTOSIS1ACCUMULATINGEVIDENCESUGGESTSTHATALTERATIONSOFMIRNASEXPRESSIONMAYPLAYVARIOUSROLESINTHEPATHOGENESISOFMANYHUMANCANCERS2,3SOMEMIRNASHASBEENSHOWNTOPOSSESSONCOGENICORTUMORSUPPRESSORACTIVITY4HIGHTHROUGHPUTTECHNIQUESHAVEBEENUSEDTOSCREENMIRNASDIFFERENTIALLYEXPRESSEDBETWEENHUMANNONMALIGNANTANDMALIGNANTSAMPLES,ANDANUMBEROFMIRNASDEREGULATEDINNUMEROUSHUMANTUMORSWEREFOUND,INCLUDINGLUNG,BREAST,LIVER,ESOPHAGEALANDPROSTATECANCERS5–9AMONGTHESEMIRNAS,MIR141,AMEMBEROFTHEMIR200FAMILY,ISOVEREXPRESSEDINOVARIANANDCOLORECTALCANCERS10,11ANDDOWNREGULATEDINPROSTATE,HEPATOCELLULAR,ANDRENALCELLCARCINOMA5,9,12,RAISINGACONTROVERSIALISSUEABOUTTHEROLEOFMIR141INCANCERPROGRESSIONELECTRONICSUPPLEMENTARYMATERIALTHEONLINEVERSIONOFTHISARTICLEDOI101007/S0053500900377CONTAINSSUPPLEMENTARYMATERIAL,WHICHISAVAILABLETOAUTHORIZEDUSERSYDU?HYU?JSIP\001SUBSTANTIALLYREDUCEDEXPRESSIONSOFMIR141WEREFOUNDINBOTHINTESTINALTYPE17FOLDN23FIG1BP\005ANDDIFFUSETYPEGASTRICCANCERS30FOLDN9FIG1CP\001THEEXPRESSIONOFMIR141INCELLLINESDERIVEDFROMGASTRICCANCERTOCONFIRMTHEASSOCIATIONBETWEENMIR141EXPRESSIONANDGASTRICCANCER,WEDETECTEDMIR141EXPRESSIONINFIG1THEEXPRESSIONOFMIR141INGASTRICCANCERQUANTIFICATIONOFMIR141WASMEASUREDBYTAQMANREALTIMEPCRALLDATAOFFOLDCHANGEWERETRANSFORMEDTOLOG2VALUESARELATIVEEXPRESSIONOFMIR141IN35PRIMARYGASTRICCANCERTISSUESCOMPAREDWITHTHEIRPAIRMATCHEDADJACENTNONTUMORTISSUESBRELATIVEEXPRESSIONOFMIR141IN23TISSUESWITHINTESTINALTYPEADENOCARCINOMARELATIVETOTHEIRPAIRMATCHEDADJACENTNONMALIGNANTTISSUESCRELATIVEEXPRESSIONOFMIR141IN9DIFFUSETYPEADENOCARCINOMATISSUESCOMPAREDWITHTHEIRPAIRMATCHEDADJACENTNONTUMORTISSUESTHEPATHOLOGICALFEATURESOFREPRESENTATIVEINTESTINALTYPEANDDIFFUSETYPEGASTRICCANCERWERESHOWNWITHHESTAININGSCALEBARS200LM558JGASTROENTEROL200944556–561123

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